Can Your DNA Determine What Diet Is Best For You? - Pathway Genomics
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Can Your DNA Determine What Diet Is Best For You?

The foods we eat, more importantly the way we metabolize these foods, play a big role in our weight management. Many times people start a diet in hopes of being able to control their weight, however more times than not, they are unsuccessful in their efforts. So why is this? Although, there are many “healthy” ways to eat, a good diet isn’t always the right one. This is because everyone is different and what might work for one, may not work for another. People are unique and the traditional “one-size-fits-all” approach simply doesn’t work. That’s where DNA testing comes in to help navigate your way down the right path.

Tailoring Nutrition to Genetics

Until recently, to find out what diet works best, one would have to figure it out on their own through years of trial and error. Now with the convenience and speed of accessing our genetic information, we can understand how we metabolize and respond to fats, proteins, carbohydrates and micronutrients to create our own unique profile and personalized diet. Our genetic makeup is what makes us different, therefore your genes help reveal why two people can eat the same foods and experience different weight gains and losses. Scientific studies have shown that eating a gene-based diet can be more effective than other standard diets (1,2). One particular study tested the power of tailored diets for weight loss; the study looked at patients with a history of failures at weight loss were offered a nutrigenetic test screening 24 variants in 19 genes involved in metabolism. 150 patients were in the nutrigenetic group and 43 patients attending the same clinic were selected for comparison using algorithms to match the characteristics: age, sex, frequency of clinical visits and BMI at initial clinic visit. The second group of 43 patients did not receive a nutrigenetic test. After 300 days of follow-up individuals in the nutrigenetic group were more likely to have maintained some weight loss (73%) than those in the comparison group (32%). In conclusion, the addition of nutrigenetically tailored diets resulted in better compliance, longer-term BMI reduction and improvements in blood glucose levels (1). In another study 500 Individuals on a diet identified as appropriate to their genotype lost an average of over 2.5 times more weight than those whose diets did not match their genotype (2).

How DNA Testing Works

DNA diagnostic tests sequence an individual’s DNA to then focus on a subset of variants, or small changes in the genetic code, that are associated with a characteristic such as how people metabolize or respond to different macronutrients: Proteins, Fats, Carbohydrates. Other important genetic factors including LDL and HDL cholesterol, blood sugar and triglycerides, which are, related to many health conditions that can be potentially prevented with the appropriate dietary changes. All the results are then calculated to determine the best diet to help you optimize your metabolism, control your weight and improve your health. An in-depth personalized report is provided with detailed actionable steps to help you make the changes necessary to optimize your efforts and maximize your results. If you want to lose weight, maintain weight, or gain weight as well as improve your overall wellness then knowing what specific diet is right for you is the best way to get the results you are seeking.


  1. Arkadianos I, Valdes AM, Marinos E, Florou A, Gill RD, Grimaldi KA. Improved weight management using genetic information to personalize a calorie controlled diet. Nut. Jour. 2008 Oct 18; 6:29 1-8. PubMed PMID: 17945020.
  2. Dopler Nelson, M. “Genetic Phenotypes Predict Weight Loss Success: The Right Diet Does Matter.” American Heart Association 50th Cardiovascular Disease Epidemiology and Prevention Conference, San Francisco, CA, March 3, 2010.