PainMedication_Header

Pain Medication DNA Insight®

Effective Prescription for Pain Medication

whatIsPainMedication_diagram_604X671

UNDERSTANDING RESPONSE TO PAIN MEDICATION AND PHARMACOGENOMICS

A variety of over-the-counter and prescription medications are available on the market today to treat pain ranging from mild to severe. However, not everyone responds to medications in the same exact way due to factors such as age, weight, general health and nutrition. In addition, an individual’s genetic makeup has been consistently shown to influence how he/she will respond to certain medications. The study of how genetics can affect drug response is known as pharmacogenomics.

OUR GENETIC TEST CAN HELP

Pain Medication DNA Insight® analyzes patients’ DNA to identify genetic variants that can affect how they respond to the analgesic effects (pain relief) of 13 commonly prescribed pain medications (see below for listing).

whatIsPainMedication_capsuleDNA

MentalHealth_HowItBenefits_infographic

CLINICAL IMPLEMENTATION FOR PATIENTS

Pain Medication DNA Insight® provides physicians with a personalized roadmap for pain medication management by helping to identify the appropriate medications and dosage for their patients.

LEARN MORE ABOUT PAIN MEDICATION DNA INSIGHT®

Genes Analyzed:

CYP2D6, CYP2B6, OPRM1

Drug Class Description:

The Opioid class of compounds has been extensively used to treat acute pain as well as to alleviate severe chronic pain associated with certain terminal conditions1.

Genes Analyzed:

CYP2C9

Drug Class Description:"

Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drugs widely used for their analgesic, anti-pyretic and anti-inflammatory properties8.

Genes Analyzed:

CYP2C19, MTHFR

Other Medications:

Step 1:

Pain Medication DNA Insight® can be ordered from a licensed and registered physician or other qualified healthcare provider.

Step 2:

The patient will provide a saliva or blood sample using the collection kit in the Pathway Genomics box.

Step 3:

The authorized physician will mail the sample back to Pathway Genomics, along with the test requisition and consent form (return shipping provided).  View the saliva collection instructional video here.  For blood collection instructions, click here.

Step 4:

Pathway Genomics processes and analyzes the submitted sample in its CLIA-certified and CAP-accredited laboratory. Typically within two to three weeks, the patient’s personalized results will be available to the ordering physician. The results will then be released to the patient. Pathway Genomics has a team of genetic counselors available to ensure that both the patient and the physician understand the information in the report, and to answer additional questions. To contact a Pathway Genomics genetic counselor, please call client services department at 877-505-7374 or email clientservices@pathway.com.

Pain Medication DNA Insight® is for patients currently taking, or considering taking a pain medication. This clinically-actionable genetic test can assist physicians in understanding patients’ response to certain pain medications, and can help with identification of optimal treatment plans.

PainMedication_2-3Weeks-MedResponse_White

HOW IT WORKS

This simple saliva- or blood-based test is supported by scientifically validated genetic testing technologies, using clinically relevant markers and assays. In just 2-3 weeks, the Pain Medication DNA Insight® report will be delivered to the physicians.

Pain-Medication-DNA-Insight-Report-3-up

REPORTS: A SIMPLE GUIDE TO UNDERSTANDING

Based on the individual’s unique genetic profile, Pain Medication DNA Insight® provides information that enables the physician to:

✓ Prescribe a more appropriate medication to avoid potentially severe and life-threatening side effects.

Find the optimal dosage for patients, and understand the lack of medication efficacy in some cases.

Avoid the misinterpretation of medication-seeking behavior.

GET THE PATHWAY GENOMICS APP TODAY!

  • Access an interactive version of your report anytime, anywhere

  • Learn about other Pathway tests and how they can help you lead a healthier life

  • Help your friends and family by sharing the power of genetic insight

downloadPTapp-apple
downloadPTapp-google
PG-App_Mobile-phone-tablet_wSh

REFERENCES

  1. Alam, A. and D.N. Juurlink, The prescription opioid epidemic: an overview for anesthesiologists. Can J Anaesth, 2015.
  2. Codeine (drug label). Roxane Laboratories, Inc. April 2013 [cited 2015 November 11]; Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022402s006lbl.pdf.
  3. Abstral (fentanyl) drug label. February 2012 [cited 2015 December 8]; Available from: http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4906457e-30ad-4da7-b3ac-bb9e6651a670.
  4. Hydrocodone. MedlinePlus Website. October 2014 [cited 2015 December 8]; Available from: https://www.nlm.nih.gov/medlineplus/druginfo/meds/a601006.html.
  5. Trafton, J.A. and A. Ramani, Methadone: a new old drug with promises and pitfalls. Curr Pain Headache Rep, 2009. 13(1): p. 24-30.
  6. Oxycodone. DrugBank website. February 2013 [cited 2015 November 11]; Available from: http://www.drugbank.ca/drugs/DB00497.
  7. Tramadol. DrugBank website. February 2013 [cited 2015 November 11]; Available from: http://www.drugbank.ca/drugs/DB00193.
  8. Medication Guide for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). [cited 2015 September 02]; Available from: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.
  9. Celebrex (celecoxib) capsule drug label. June 2015 [cited 2015 November 11]; Available from: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=8d52185d-421f-4e34-8db7-f7676db2a226.
  10. Cataflam (diclofenac) tablet drug label. [cited 2015 September 02]; Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020142s021s022lbl.pdf.
  11. Zorvolex (diclofenac) capsule drug label. [cited 2015 September 02]; Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204592s002s004lbl.pdf
  12. Bort, R., et al., Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways. Biochem Pharmacol, 1999. 58(5): p. 787-96.
  13. Ansaid tablet (drug label). [cited 2015 September 02]; Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/018766s015lbl.pdf.
  14. Ibuprofen [cited 2015 September 02]; Available from: https://www.nlm.nih.gov/medlineplus/druginfo/meds/a682159.html.
  15. Mobic (meloxicam) drug label. [cited 2015 September 02]; Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020938s022lbl.pdf.
  16. Gupta, A., et al., Carisoprodol-induced amnestic state. Indian J Psychiatry, 2008. 50(1): p. 72-3.
  17. Methotrexate. DailyMed website. September 2015 [cited 2015 December 8]; Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d71b1856-99d8-4a9e-9189-f87b6675f80a.