Genetic Test for Lynch Syndrome
What is LynchSyndromeTrue™?
LynchSyndromeTrue™ analyzes the coding and flanking regions (+/- 20 bp) of 4 genes associated with Lynch Syndrome (MLH1, MSH2, MSH6, and PMS2) by next-generation sequencing-based (NGS) and Sanger confirmation of reported gene variants. Sanger fill-in is used for all genes in areas of low coverage, which is defined as a read depth of less than 25x. Gross deletions and duplications in the aforementioned 4 genes and EPCAM are identified by microarray analysis and multiplex ligation-dependent probe amplification (MLPA). Suspected deletions in exons 13-15 of PMS2 are confirmed with long range PCR to exclude the pseudogene signal.
The saliva sample collection kit includes one saliva collection device. Fill each tube up to the notch in the collection device.
The blood sample collection kit includes one 4ml lavender blood tube.
For more information about the sample collection kits listed above, please contact our client services department at (877) 505-7374 or firstname.lastname@example.org. To order sample collection kits, complete our online order form.
History of early onset colorectal or endometrial cancer (<50 yrs)
Two or more associated cancers* in the same individual
History of colon adenomas under 50 year of age
Multiple family members, on the same side of the family, with the same type of cancer or associated cancers*
Abnormal MSI and/or IHC testing
*Associated cancers are listed in the table below.