Cardiac DNA Insight®

Genetic Testing for Heart Health

Genetics and Cardiovascular Diseases

According to the Centers for Disease Control and Prevention (CDC), heart disease is the leading cause of death in the U.S. for both men and women. Many factors contribute to the risk of developing heart disease, including personal genetics and family history, nutrition and exercise, hypertension, high blood pressure and cholesterol levels. In addition, an individual’s unique genetic makeup can influence how he/she will respond to medications used to treat heart conditions.

How Our Genetic Test Can Help

DNA testing with Cardiac DNA Insight® analyzes patients’ DNA to identify specific genetic variants associated with an increased risk of developing certain heart-related health conditions such as hypertension, atrial fibrillation and myocardial infarction. This test also provides insight into patients’ potential responses to eight classes of commonly prescribed medications that are used to treat heart-related conditions or are known to affect the cardiovascular system.

Clinical Implementation for Patients

Cardiac DNA Insight® provides physicians with information about their patients’ genetic risks of various heart-related health conditions. Cardiac DNA Insight® empowers the physician to help patients make informed decisions regarding diet and exercise, while also providing information about medication response. Our easy-to-read genetic test reports provide actionable information and recommendations that provide individuals with a roadmap to achieve optimal heart health.

More About Cardiac DNA Insight®

Heart Disease/Atrial Fibrillation

– Atrial fibrillation

– Beta-blockers, LVEF response

– Caffeine metabolism

– Coronary artery disease

– Myocardial infarction

– Simvastatin-induced myopathy

– Verapamil and QTc interval

Peripheral Arterial Disease/Venous Thrombosis

– Clopidogrel metabolism (Plavix)

– Estrogen supplementation (risk of venous thrombosis)

– Peripheral arterial disease

– Venous thrombosis

– Warfarin


– Beta-blockers

– Hypertension

– Metoprolol metabolism

– Perindopril (ACE inhibitor-therapeutic benefit)

– Verapamil vs. atenolol (benefit of)

Cardiovascular Health

– ApoE and cardiovascular disease

– Genetic risk for decreased folate

– Genetic risk for decreased HDL cholesterol

– Genetic risk for elevated LDL cholesterol

– Genetic risk for elevated triglycerides

– Sickle cell anemia

Step 1:

Cardiac DNA Insight® can be ordered by an online physician designated by Pathway Genomics on your behalf.

Step 2:

Once your test has been ordered for you by a physician, you will provide a saliva sample using the saliva collection kit found in the Pathway Genomics box.

Step 3:

You or your authorized health care professional will mail your saliva sample back to Pathway Genomics, along with your test requisition and consent form (return shipping provided). View our saliva collections instructional video here.

Step 4:

Pathway Genomics processes and analyzes the submitted sample in its CLIA certified and CAP accredited laboratory. Typically within two to three weeks, the patient’s personalized results will be available to the ordering physician. The results will then be released to the patient. Pathway Genomics has a team of genetic counselors available to ensure that both the patient and the physician understand the information in the report, and to answer additional questions. To contact a Pathway Genomics genetic counselor, please call client services department at 877-505-7374 or email

Cardiac DNA Insight® is intended for individuals who want to learn more about their genetics in order to leverage this information to manage and optimize their heart health.

How It Works

This simple saliva or blood-based test is supported by scientifically validated genetic testing technologies, using clinically relevant markers and assays. In just 2-3 weeks, the Cardiac DNA Insight® report will be delivered to the physicians.

Reports: A Simple Guide to Understanding

Cardiac DNA Insight® provides information that allows physicians to:

Better understand a patients’ risk for specific cardiac-related health conditions

Prescribe more suitable medications at optimal dosages for patients, as needed.

Suggest early lifestyle and diet interventions to help control or prevent certain health conditions.

View Sample Report

Get the Pathway Genomics App today!

  • Access an interactive version of the report anytime, anywhere
  • Learn about other Pathway tests and how they can help lead a healthier life
  • Help friends and family by sharing the power of genetic insight
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